ChannelsDB 2.0 was published in an article

In 2018, the first version of the ChannelsDB database was published. Now, its second version was made public in the article ChannelsDB 2.0: a comprehensive database of protein tunnels and pores in AlphaFold era published in the Database issue of the Nucleic Acids Research journal. ChannelsDB 2.0 results from a broad cooperation between Palacký University, the Loschmidt Laboratories, the RECETOX, the International Clinical Research Center at St. Anne's University Hospital, and the Structural Bioinformatics research group.

ChannelsDB 2.0 provides, as did its predecessor, structural information about the position, geometry, and physicochemical properties of protein tunnels (i.e. channels and pores). It supports input structural data not only from the Protein Data Bank but also from the popular but huge AlphaFoldDB. Aside from tunnels discovered by MOLE, the database now houses tunnels discovered by the CAVER tool. And last, but by no means least, the second version of the ChannelsDB provides tunnels that start from cofactors within the AlphaFill database. Therefore, it is no surprise that it contains approximately 4.6 times more channel annotations than the ChannelsDB 1.0.